OSMOMETRIC BEHAVIOR OF NORMAL HUMAN ERYTHROCYTES

Osmometric Behavior of Normal Human Erythrocytes.

It is generally accepted that when erythrocytes are suspenided in hypotonic solutions thev first take up water and swell, and theni at some critical tonicity burst and allow hemoglobin to escape. While there are many indications that the permeability of these cells to both salts and water may vary considerably in different conditions (1, 2, 3), quantitative data on the osmometric behavior of ei...

Osmometric behavior of normal and abnormal human erythrocytes.

By GEORGE M. GUEST, M.D. V ARIOUS investigators have postulated two main principles which seem to govern the swelling and hemolysis of red blood cells suspended in hypotonic salt solutions: namely, the cells imbibe water according to the laws of osmosis, and their maximum swelling is limited by an inelastic surface membrane. According to this concept, hemolysis occurs when the erythrocytes in h...

7Li NMR of Normal Human Erythrocytes

Lithium has been known to be an effective medication forpeople withbipolar disorder. The mechanisms of action of lithium in the brain isnot very well understood. NMR spectroscopy and imaging are effective both in determining lithium levels in tissue and brain. We have monitored lithium levels in red blood cells. We have been able to separate intraand extracellular compartments oflithium using s...

Transmembrane orientation of the glycoproteins in normal human erythrocytes.

The Chromatography of Hemins from Normal and Abnormal Human Erythrocytes.

By C. RICHARD L , ARTHUR HAUT, THOMAS H. CAINE, GEORGE E. CARTWR.LGHT AND MAXWELL M. WINTROBE F ISCHER determined the chemical structure of protohemin, the prosthetic group of hemoglobin, in 1929.’ Since that time, it has been widely assumed that protohemin is a homogeneous compound and that its chemical structure does not vary in health or in disease. This assumption has survived an era noted ...